HomeIndustriesMayo Clinic researchers are developing “hypothesis-driven AI” for oncology

Mayo Clinic researchers are developing “hypothesis-driven AI” for oncology

Mayo Clinic researchers have developed an revolutionary AI technology called “hypothesis-driven AI,” which deviates from traditional data-driven AI models.

Traditional AI methods are excellent at recognizing patterns in large amounts of knowledge comparable to genetic sequences or diagnostic images, but often cannot directly integrate existing scientific knowledge or hypotheses into their learning process.

Hypothesis-driven AI challenges these norms by incorporating medical hypotheses into its learning process. Not only does it learn from the info fed to it, but it surely also uses hypotheses to look at data directly.

Documentation of yours Research within the magazine CancersMayo Clinic uses its hypothesis-driven AI systems to unravel the dynamics of complex diseases like cancer.

Write in a Mayo Clinic press releaseDr. Hu Li, the study's lead writer, explained the advantages of hypothesis-driven AI medical research: “This ushers in a brand new era in the event of targeted and informed AI algorithms to resolve scientific questions, higher understand diseases and guide individualized medicine.”

This is how it really works:

  • Compile data: The team led by Zilin Xianyu and colleagues at Mayo Clinic began their study by collecting genomic (DNA), proteomic (proteins), transcriptomic (RNA messages), and epigenetic (inheritable changes that don’t affect the DNA sequence information) data impact). Thousands of cancer samples.
  • Development of the AI ​​system: Building on the info collected, the researchers developed a novel class of AI algorithms generally known as “hypothesis-driven AI.” Unlike traditional models, these algorithms are specifically designed to integrate and test scientific hypotheses into their learning process.
  • Application for oncology research: With the algorithms ready, researchers applied their hypothesis-driven AI to several key areas of oncology research, comparable to tumor classification, patient stratification, and drug response prediction, and reported improved performance over traditional methods.
The authors' presentation of how hypothesis-driven AI works. Source: Mayo Clinic.

Daniel Billadeau, Ph.D., co-investigator of the study and professor within the Division of Immunology at Mayo Clinic, explained, “This latest class of AI opens a brand new avenue for a greater understanding of the interactions between cancer and the immune system and continues to achieve this.” Great promise not only to check medical hypotheses but in addition to predict and explain how patients will reply to immunotherapies.”

Of course there are some limitations. Dr. Li points out the challenges of developing such advanced algorithms, including the necessity for domain-specific research and the danger of bias.

Still, he stays optimistic, explaining, “Nevertheless, hypothesis-driven AI facilitates energetic interaction between human experts and AI, alleviating concerns that AI will ultimately eliminate some skilled jobs.”

The role of AI in medical and healthcare research is continually evolving, with recent advances being made New antibiotic research and synthesize Anti-aging drugs.

Mayo Clinic researchers recently used GPT-4 as a diagnostic Aids for stroke patients, and last yr they helped develop a machine learning model that might do that Diagnose diabetes using voice recordings.

However, there are risks, because the production of guidelines by greater than 100 researchers made clear secure AI protein design to limit the potential for abuse.


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